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Building knowledge for gene/cell therapyProviding toolsto acceleratetheof advanced therapiesdiscover moredevelopment
New model systems
Developing improved and sustainable model systems for predicting product safety
Therapy improvement
Enhancing gene therapy vectors for better immune evasion and stability
Regulatory engagement
Establishing a comprehensive database on safety and efficacy of advanced therapies
About ARDAT
A new consortium of 34 international partners from academia, industry, and small/medium enterprises with the aim to develop and provide tools to advance our knowledge in the field of viral gene/cell therapy to accelerate the development of new treatments for rare diseases

Project structure
ARDAT
Accelerating Research & Development for Advanced Therapies
Work package 1
Project management to specify processes and principles
Work package 2
Standardized models for predicting product immunogenicity
Work package 3
Understanding of gene/cell therapy drug metabolism
Work package 4
Clinical factors around pre-existing immunity
Project structure
Work package 1
Project management to specify processes and principles
Work package 2
Standardized models for predicting product immunogenicity
Work package 3
Understanding of gene/cell therapy drug metabolism
Work package 4
Clinical factors around pre-existing immunity
Work package 5
Engagement with regulators and database development
Principal project objectives
Pre-clinical studies
Developing standardized models for predicting immunogenicity
Vector enhancement
Understanding gene/cell therapy drug molecular stability and metabolism
Clinical research
Investigating clinical factors around pre-existing immunity
Data Processing & Analysis
Establish a comprehensive and sustainable database on safety and efficacy of advanced therapies