New model systems
Developing improved and sustainable model systems for predicting product safety
Therapy improvement
Enhancing gene therapy vectors for better immune evasion and stability
Regulatory engagement
Establishing a comprehensive database on safety and efficacy of advanced therapies
About ARDAT
A new consortium of 34 international partners from academia, industry, and small/medium enterprises with the aim to develop and provide tools to advance our knowledge in the field of viral gene/cell therapy to accelerate the development of new treatments for rare diseases
Project structure
ARDAT
Accelerating Research & Development for Advanced Therapies
Work package 1
Project management to specify processes and principles
Work package 2
Standardized models for predicting product immunogenicity
Work package 3
Understanding of gene/cell therapy drug metabolism
Work package 4
Clinical factors around pre-existing immunity
Project structure
Work package 1
Project management to specify processes and principles
Work package 2
Standardized models for predicting product immunogenicity
Work package 3
Understanding of gene/cell therapy drug metabolism
Work package 4
Clinical factors around pre-existing immunity
Work package 5
Engagement with regulators and database development
Principal project objectives
Pre-clinical studies
Developing standardized models for predicting immunogenicity
Vector enhancement
Understanding gene/cell therapy drug molecular stability and metabolism
Clinical research
Investigating clinical factors around pre-existing immunity
Data Processing & Analysis
Establish a comprehensive and sustainable database on safety and efficacy of advanced therapies
