Our ARDAT colleague Catarina Brito (iBET) and other ARDAT researchers have published their work on the developed scalable hiPSC-derived 3D CNS model combining neurons, astrocytes, oligodendrocytes and microglia to mimic neuroinflammation. The model reproced neuron-microglia crosstalk and inflammatory responses, including early rAAV9-induced TNF/NF-kB activation, supporting preclinical CNS gene therapy development.
Further details about the Advanced Science publication can be accessed via the link.